Ethan Hunt and his IMF team embark on their most dangerous mission yet: To track down a terrifying new weapon that threatens all of humanity before it falls into the wrong hands. With control of the future and the fate of the world at stake, and dark forces from Ethan's past closing in, a deadly race around the globe begins. Confronted by a mysterious, all-powerful enemy, Ethan is forced to consider that nothing can matter more than his mission – not even the lives of those he cares about most.

England has been overrun by a pandemic with no apparent cure. As the infection continues to spread, safety - for a lucky few - looms in the form of a damaged 747 set to seek solace abroad. It's only once the plane is airborne that the survivors discover the infection made it onto the flight with them.